Another interesting marker for the prediction of response to treatment based on nucleoside analogs is the presence in the tumor cell plasma membrane of the equilibrative nucleoside transporter 1 (ENT1, gene symbol SLC29A1), which has been associated with better outcome in patients receiving gemcitabine as an adjuvant in resected CCA and as first-line treatment in advanced biliary tract cancer [9,10]. Here, SLC29A1 is linked to biliary tract neoplasm.