The inhibition of the nuclear factor kappa B (NF-κB) by the synthetic compound dehydroxymethylepoxyquinomicin (DHMEQ) also enhances the sensitivity of CCA cells to several antitumor drugs, such as 5-FU, cisplatin and doxorubicin, presumably due to its ability to induce MDR1 and BCRP downregulation [66]. The gene discussed is ABCG2; the disease is cholangiocarcinoma.