In the same year, a karyotype-specific microRNA signature was described in CLL patients [49], and the mechanism for the activation of the vascular endothelial growth factor (VEGF)-based autocrine pathway in CLL B-cells was elucidated, involving miR-92-1 (also known as miR-92a-3p), which is overexpressed in CLL B-cells. The gene discussed is VEGFA; the disease is B-cell chronic lymphocytic leukemia.