Rhabdomyosarcomagenesis involves, in part, the prolonged activation of serine/threonine kinases such as AKT [60], and we have previously shown that AKT1 and AKT3 phosphorylation stabilizes the TBX3 protein in chondrosarcoma/fibrosarcoma and melanoma, respectively [50,71]. Here, AKT3 is linked to chondrosarcoma.