For example, TBX3 bypasses senescence by repressing p14/p19ARF in breast cancer and promotes proliferation by repressing p21WAFI/CIPI/SDII (referred to as p21) in chondrosarcoma, p57KIP2 in papillary thyroid carcinoma, or phosphatase and tensin homologue (PTEN) in head and neck squamous cell carcinoma [24,28,30,31]. The gene discussed is CDKN2A; the disease is thyroid gland papillary carcinoma.