Indeed, in melanoma, AKT3 is the most abundant isoform and AKT phosphorylation of TBX3 enhances protein stability, nuclear localisation and transcriptional activity [71]; in fibrosarcoma and chondrosarcoma, AKT1 is the predominant isoform and it maintains high levels of TBX3 [72]. Here, AKT3 is linked to chondrosarcoma.