Since NKA is both a key driver of alveolar fluid clearance and also a central cell adhesion molecule in the alveolar epithelium that is pivotal for prevention of alveolar edema formation, these novel findings may lead to novel therapeutic options that improve resolution of alveolar edema and restores alveolar epithelial barrier function in patients with ARDS and hypercapnia. This evidence concerns the gene TAC1 and acute respiratory distress syndrome.