ABCG2 and neoplasm: In order to investigate the effect of EC16-1/saporin on the ABCG2-overexpressing tumors, the parental (NCI-H460) and ABCG2-overexpressing (NCI-H460/MX20) cells were implanted into athymic nude mice to create the ABCG2-overexpressing tumor xenograft model.