HJV and hereditary hemochromatosis: In addition, the live Pgm− strain (Y. pestis KIM5) retained virulence by intranasal (i.n.)or intravenous (i.v.)administration [6,8,9,10], caused fatal septicemic plague in an individual with hereditary hemochromatosis manifesting as iron overload in tissues [11], and restored its virulence in hemojuvelin-knockout (Hjv−/−) mice mimicking human hereditary hemochromatosis [12].