Its use in AD has been widely examined and tracer retention correlated with post mortem neurofibrillary tangles (NFTs) containing tau in the form of paired helical filaments [Marquié et al., 2015, Lemoine et al., 2017, Jovalekic et al., 2017, Xia et al., 1]. The gene discussed is MAPT; the disease is Alzheimer disease.