APOE and Alzheimer disease: Earlier studies reported that African Americans and Hispanics have an increased frequency of AD regardless of their APOE genotype, however the most recent literature showed that APOE4 has a weak association with AD incidence amongst African Americans and Hispanics, in comparison to white populations [Tang et al., 11, Blue et al., 2019, Rajabli et al., 2018, Yu et al., 2017, KB Rajan et al., 2019].