In summary, dimethylpyrrole‐based BODIPY dyes connected with the targeting senicapoc moiety through an ethyl linker (25) represents a promising new small‐molecule probe for selective imaging of KCa3.1 channels of NSCLC cells in vitro and in vivo using a simple, fast, and efficient staining protocol. The gene discussed is KCNN4; the disease is non-small cell lung carcinoma.