This finding suggested that hyperglycemia may have contributed to the aberrant activation of Ly6Chigh monocytes; however, treatment of db/db mice with luseogliflozin had little effect on gene expression, with the exception of S100a8 and S100a9. We attempted to evaluate the effect of insulin resistance alone on inflammatory changes in bone marrow monocytes. The gene discussed is S100A8; the disease is Hyperglycemia.