DCC and neurodevelopmental disorder: Although direct evidence linking Dcc to tumorigenesis was obtained in mice (Castets et al., 2012; Krimpenfort et al., 2012), mutations in DCC were also identified in patients suffering from rare neurodevelopmental disorders including congenital mirror movements (Depienne et al., 2011; Srour et al., 2010) and corpus callosum dysgenesis (Jamuar et al., 2017; Marsh et al., 2017).