Transcriptional misregulation in cancer (map05202 on KEGG database: ://www.genome.jp/kegg/pathway.html) pathway was one of the top pathways identified, which derived from multiple TF alterations, including genes fusion, amplification, mutation, deletion, rearrangements and translocation, resulting in various oncogenic processes such as differentiation resistance, inhibition of apoptosis, and cellular invasion. The gene discussed is TF; the disease is cancer.