Patients with ALL bearing MLL‐rearrangements show poor survival also due to cellular resistance to various chemotherapeutics, especially to GC, which is in accordance with the results of KEGG analysis.27 Notably, CCND2 is upregulated and hyperactivated by the amplification of transcription factors with oncogene properties, and thereby accelerates cell cycle by promoting G1/S phase transformation and increasing cell proliferation, which is considered the critical oncogenesis process in leukemia and lymphoma. The gene discussed is KMT2A; the disease is leukemia.