Despite the reassuring achievements in the treatment of patients with ALL, resistance to GC agonists has been a major obstacle in eliminating leukemia cells and maximizing cure.24 Several studies on GC resistance have elucidated that GC‐stimulated apoptosis is not induced in leukemia cells with poor response to GC agents.25, 26 Recently published articles partly expanded our understanding about the molecular mechanism of GC resistance, wherein the role of some molecules and signaling pathways including MLL rearrangement and JAK/SAT pathway alteration were determined. The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.