Moreover, MYC overexpression promoted resistance to Btk inhibition in B cell malignancy.34 Notably, the GC resistance‐promoting role of MYC in ALL was firstly elucidated by Renner K.35 Han et al revealed that MYC displays constitutive activation in B‐ALL cell lines, especially GC‐resistant B‐ALL, indicating the critical role of MYC in evolution of GC resistance.26 The positive impact of MYC on progression of GC resistance in ALL was subsequently strengthened by other studies.36, 37 Hence, the results of PPI network were in accordance with experimental results on GC resistance in ALL. The gene discussed is MYC; the disease is acute lymphoblastic leukemia.