Nevertheless, AFP sensitivity in diagnosing HCC is only 60% at the most efficient cut‐off value (10‐20 ng/mL) with low specificity,6 owing to serum AFP being also positive in cirrhosis, hepatitis and other malignancies.7 Thus, the use of serum AFP for the accurate diagnosis of HCC is controversial and confused. The gene discussed is AFP; the disease is Cirrhosis.