It was reported that only 60%‐70% of patients with HCC had observed elevated serum AFP, and up to 30% of HCC patients showed negative serum AFP.8 HCC patients with negative serum AFP have special clinicopathologic characteristics and prognosis, thus, a reliable model to accurately predict prognosis of AFP‐negative HCC may be of value for guiding clinical decision making. The gene discussed is AFP; the disease is hepatocellular carcinoma.