CNVs are duplications or deletions of continuous base pairs of genes, and several studies have found that higher frequencies of CNVs always predict a worse prognosis in tumor patients.56, 57 CNVs were also found to be associated with resistance to ICIs such as anti‐CTLA‐4 therapy in melanoma.54 Our study also found that the frequencies of genomic CNVs were higher in low‐infiltrating TMEs than in high‐infiltrating TMEs. The gene discussed is CTLA4; the disease is melanoma.