The enrichment scores of 50 biological pathways were calculated for MIBC patients in the TCGA‐BLCA cohort, and we found that patients with a low‐infiltrating TME had higher enrichment scores of tumor proliferation‐associated pathways such as the MYC target, the G2M checkpoint, DNA repair, and MTORC1 signaling, and patients with a high‐infiltrating TME had higher enrichment scores of immune‐associated pathways such as the inflammatory response, allograft rejection, epithelial‐mesenchymal transition, and complement (Figure S3A). This evidence concerns the gene MYC and bladder transitional cell carcinoma.