CD3D and neoplasm: For example, CIITA can trigger antitumor immunity by inducing the expression of the MHC class II molecules of tumor cells,41 CD3D can regulate the proliferation and development of T cells,42, 43 and GNLY can encode granulysin, which can cause the lysis of tumor cells.44 Interestingly, using the median TIM score as a cutoff value, we observed that the genes of patients with high TIM scores were enriched in protumor pathways and that the genes of patients with low TIM scores were enriched in inflammatory pathways.