Together, our data suggest that epithelial expression of the pro‐allergic cytokine, IL‐13, can drive corticosteroid‐resistant asthma which is mediated by epithelial EGFR/ERBB signalling driving a gene signature and phenotypic responses that are more classically associated with IL‐17 and Th17 immune responses. This evidence concerns the gene EGFR and asthma.