In multiple myeloma cells, this activation of Beclin‐1 is impeded by the presence of FLIP(L): DED‐mediated heterodimerization of procaspase‐10 and FLIP(L) results in a complex possessing proteolytic activity that cleaves the BCL2‐interacting protein Bcl‐2 associated transcription factor 1 (BCLAF1). The gene discussed is CFLAR; the disease is AL amyloidosis.