To increase the tumor-to-background ratio of the drug, Tavare et al. performed the reformatting CD166-targeted agents (64Cu-DOTA-3 L-amide-cDb and 64Cu-DOTA-3 L-thioether-cDb) on a CD166-overexpressed colorectal cancer (LS174T) xenograft model [50]. Here, ALCAM is linked to colorectal cancer.