IL4 and neoplasm: M0, M1, and M2 macrophages can reside simultaneously in the tumor tissues, and undifferentiated macrophages (M0) can be readily induced by cytokines and other stimuli, such as interferon-γ (IFNγ) and/or lipopolysaccharide (LPS) orient to M1 phenotype, and combination of IL4/IL13 orient to M2 macrophages, respectively [64–66].