NSD2 and plasma cell myeloma: Chromosomal aberrations are frequently used to stratify patients with multiple myeloma (MM), and the t(4;14) translocation and 17p13 deletion are consistently associated with poor survival.1, 2, 3 In cells, t(4;14) is transposed upstream of the Nuclear Receptor Binding SET Domain Protein 2 gene (NSD2, previously named WHSC1 and MMSET), leading to its ectopic overexpression.4 NSD2 overexpression is found in all t(4;14) positive MM patients, and NSD2 knockdown induces cell death in MM cells lines.