This conclusion is supported by the following lines of evidence: (a) ACA11 overexpression induced an increase in nucleoli number and size as well as in AgNOR numbers in both MM cells lines and patients; (b) ACA11 overexpression upregulated the available pool of cytosolic ribosomes in MM cell lines; (c) MM cells overexpressing ACA11 had both increased cellular mass and an increased rate of new protein synthesis; and (d) ACA11‐induced ROS drove increased protein synthesis and pre‐47S rRNA levels. The gene discussed is SCARNA22; the disease is Miyoshi myopathy.