Running upregulated expression of Col III and insulin-like growth factor (IGF)-I, but downregulated TGFβ1, connective tissue growth factor (CTGF), and ECM components fibromodulin and biglycan, with no impact on Col I. Notably, these gene expression profiles are not observed in human tendinopathies [144]. This evidence concerns the gene TGFB1 and disease of the tendon.