ERBB2 and colorectal carcinoma: Previous studies have evaluated variety of genetic changes that appear to influence the prognosis of CRC patients, including microsatellite instability (MSI), RAS mutation, BRAF mutation, the human epidermal growth factor receptor 2 gene (HER2) (De Roock et al., 2010; Liu et al., 2017, 2018; Noda et al., 2018; Salvia, Lopez-Gomez & Garcia-Carbonero, 2018).