In the present study, the mutation rates of BRAF was 3.96%, the BRAF mutation rate is similar to that previously reported in Iranian (5.8%, 15/258) (Nazemalhosseini-Mojarad et al., 2019), but significantly lower than the value of 16% among 1185 CRC patients from Norway (Smeby et al., 2018). Here, BRAF is linked to colorectal carcinoma.