In the present study, we found that the dysregulated lncARNA-mRNA pairs (NONRATG017315.2-Pdk4, NONRATG003318.2-Stc2, NONRATG011882.2-Il15, NONRATG013497.2-Fbxw7 and MSTRG.1662-Ucp3) might be implicated in hyperglycemia, glucose intolerance, as well as dysregulated glucose and fatty acid oxidation in GK rats at 3 and 4 weeks of age. Here, FBXW7 is linked to Hyperglycemia.