Since targeted lncRNAs of these significantly downregulated mRNAs had a high correlation coefficient, the co-expressed pairs lncRNA-mRNA pairs, such as NONRATG003318.2-Stc2, NONRATG011882.2-Il15, and NONRATG013497.2-Fbxw7 be related to hyperglycemia and impaired glucose tolerance in GK rats at the age of 3 and 4 weeks. This evidence concerns the gene FBXW7 and Impaired glucose tolerance.