In this study, we show that the expression of orthodenticle homeoproteins, OTX1 and OTX2, which participate to neuroplastic changes both in physiological and pathological conditions (Spatazza et al., 2013), is up-regulated in the myenteric plexus of the rat small intestine and distal colon after an experimentally induced colitis with DNBS acid. The gene discussed is OTX2; the disease is colitis.