E2F1 and hepatocellular carcinoma: There are numerous targets of miR-193a-3p, among which serine- and arginine-rich splicing factor 2 (SRSF2), E2F transcription factor 1 (E2F1), and Mcl-1 have been proven to inhibit the development and progression of HCC (Khordadmehr & Shahbazi, 2019; Kwon et al., 2013; Ma et al., 2012; Salvi et al., 2013).