FAM135B and esophageal squamous cell carcinoma: For ESCC, researchers have identified multiple driving genes, including TP53, NOTCH1, FAM135B, EP300, and TET2, and the mutation status of FAM135B, EP300 and TET2 are associated with the prognosis of patients (Gao et al., 2014; Sawada et al., 2016; Song et al., 2014).