Chromatin-modifying genes (ASXL1 and EZH2) were associated with transformed acute leukemia, and Delic et al. [22] used second-generation gene sequencing to determine that ASXL1 and EZH2 mutations were frequently mutated in PMF patients but rarely mutated in ET and PV patients. Here, ASXL1 is linked to essential thrombocythemia.