Mechanistically, the traffic of DCs from brain tumor to CLNs and its antigen presentation may contribute to the activation of CD8+ T cell against brain tumor, which was proposed to be enhanced by subcutaneous tumor.49 Indeed, the ablation of dorsal MLVs resulted in decreased DC drainage into CLNs in mice bearing intracranial GL261 and B16 tumors (Fig. 3d). Here, CD8A is linked to brain neoplasm.