In the week-by-week study, ApoE−/− mice with AAAs showed an average increase of 154% ± 12% in aortic diameter after 1 week, of 168% ± 15% after 2 weeks, and of 243% ± 19% after 4 weeks (Supplemental Fig. 1). This evidence concerns the gene APOE and achalasia-alacrima syndrome.