Among 2,039 DIPs, there is no common DIP, however, AKT1 (AKT Serine/Threonine Kinase 1), CTNNB1 (Catenin Beta 1), GRB2 (Growth Factor Receptor Bound Protein 2), HDAC1 (Histone Deacetylase 1), and HSP90AB1 (Heat Shock Protein HSP 90-Beta), which have already been associated with cancer hallmarks in COSMIC Cancer Gene Census (CGC) catalogue18, were the common proteins exhibiting DIP characteristics in eleven of all the cancers investigated. The gene discussed is CTNNB1; the disease is cancer.