AKT1 and cancer: Among 2,039 DIPs, there is no common DIP, however, AKT1 (AKT Serine/Threonine Kinase 1), CTNNB1 (Catenin Beta 1), GRB2 (Growth Factor Receptor Bound Protein 2), HDAC1 (Histone Deacetylase 1), and HSP90AB1 (Heat Shock Protein HSP 90-Beta), which have already been associated with cancer hallmarks in COSMIC Cancer Gene Census (CGC) catalogue18, were the common proteins exhibiting DIP characteristics in eleven of all the cancers investigated.