SERPINE2 and hemangioma: The drastic down-regulation of the Serpin family E member 2 (SERPINE2) in both the proliferative and involution phases of hemangiomas with respect to placenta tissue reported by Calicchio25 was probably an artifact and not necessarily related to hemangioma development since RNA-seq experiments from the Human Protein Atlas26 show very high expression levels (TMP values) in placental tissue under homeostatic conditions.