Fibroid tumors stratify into four main subtypes that are dependent on the mutational status of mediator of transcription subunit 12 (MED12), fumarate hydratase (FH), high mobility group AT-hook 2 (HMGA2) translocations, and collagen (COL4A5-COL4A6) gene deletions7. The gene discussed is MED12; the disease is leiomyoma.