Identified examples of genes that, despite being overexpressed in leiomyomas, do not show a significant change in promoter H3K27 acetylation include fibronectin 1 (FN1), a disintegrin and metalloprotease domain-containing protein 19 (ADAM19), and collagen gene COL12A1, key genes involved in ECM formation and degradation (Fig. 2e, f and Supplementary Fig. 2c). The gene discussed is ADAM19; the disease is leiomyoma.