In fact, ZEB1 inhibits gene expression not only by direct DNA binding, but also by forming a repressor complex with Sirt1, a class III histone deacetylase (HDAC), to bind the promoter of E-cadherin, leading to E-cadherin expression silencing and the induction of EMT in prostate and pancreatic cancer cells10,11. This evidence concerns the gene CDH1 and pancreatic neoplasm.