Similar results in terms of increased GSK3βS9 phosphorylation have also been reported with in vivo administration of huperzine A and analogs to 3xTg-AD mice containing transgenes expressing three mutations associated with familial Alzheimer’s disease (APP Swedish, MAPT P301L, and PSEN1 M146V)83. Here, PSEN1 is linked to familial Alzheimer disease.