Genetic variations in Myh9 are associated with a predisposition to chronic kidney disease (CKD) and other renal injury including human immunodeficiency virus-associated collapsing glomerulopathy, focal segmental glomerulosclerosis, hypertension-attributed end-stage kidney disease, and diabetes-attributed end stage kidney disease. The gene discussed is MYH9; the disease is focal segmental glomerulosclerosis.