SIRT1 and steatosis: Of particular interest in this respect, PHH with FFA-induced steatosis displayed a decrease in the expression of the genes encoding microtubule associated proteins 1A/1B light chain 3 beta (LC3; also known as MAP1LC3B) and sirtuin-1 (SIRT1), two markers of autophagy activation (Tong et al., 2016) (Fig. S1A,B).