MAPT and frontotemporal dementia: However, under pathophysiological conditions, abnormal hyperphosphorylation of tau at numerous toxic epitopes has been extensively reported in the context of AD and related tauopathies, including corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick’s disease (PD), and frontotemporal lobar degeneration (FTLD) [4, 5].