Moreover, a cocktail treatment of SMN2 splice-switching oligonucleotides (SSOs), which enhanced inclusion of exon 7 to generate functional SMN2, with SMN-AS1 ASOs enhanced mean survival of SMA mice from 18 days to 37 days, with ~25% of the mice surviving more than 120 days [33]. The gene discussed is SMN1; the disease is proximal spinal muscular atrophy.