Both C9ORF72 sense (C9ORF72-S) and antisense (C9ORF72-AS) transcripts harboring hexanucleotide expansions could be translated into poly-dipeptides and were found in the MNs of C9ORF72-associated ALS patients [47, 50, 95, 121, 151, 163]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.