Although crosslinking and immunoprecipitation assay (CLIP) has revealed that NEAT1 associates with TDP-43 [103, 137, 154] and FUS/TLS [103], the first evidence linking NEAT1 and paraspeckles to ALS was the observation of co-localization of NEAT1_2 with TDP-43 and FUS/TLS in paraspeckles of early-onset ALS patients [103]. Here, NEAT1 is linked to amyotrophic lateral sclerosis.