Knockdown of a transcription elongation factor, Spt4, rescues C9ORF72-mediated pathology in a Drosophila model and decreases C9ORF72-S and -AS transcripts as well as poly-Gly-Pro protein production in iPSC-derived neurons from a C9ORF72-associated ALS patient [66]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.