In contrast, another study suggested that compared to C9ORF72-S-generated dipeptides (poly-Gly-Ala and poly-Gly-Arg), fewer dipeptides (poly-Pro-Arg and poly-Pro-Ala) derived from C9ORF72-AS were found in the CNS region of C9ORF72-associated FTD patients [83]. This evidence concerns the gene C9orf72 and frontotemporal dementia.