EZH2 and Familial prostate cancer: For example, consistent with the previous report, we observed a bimodal distribution of the H3K27me3 signal at EZH2 ChIP-seq peaks in LNCaP-abl (abl) cell line, an androgen-independent prostate cancer cell line (Fig. 1b), where the two modes represent classical and non-classical binding sites of EZH2, respectively.