The aim of this study was to explore the relationship of PNPLA3 I148M and TM6SF2 E167K variants with the risk of CHD in NAFLD patients in Chinese Han population, and explore the effects of PNPLA3 I148M and TM6SF2 E167K variants on the serum lipid profiles in overall series. This evidence concerns the gene PNPLA3 and coronary artery disorder.