In consideration of the tightly association of NAFLD and CHD in patients, and PNPLA3 I148M and TM6SF2 E167K variants may possess the joint effect to conferred to the higher risk of NAFLD, it is meaningful to investigate the correlation of PNPLA3 I148M and TM6SF2 E167K variants with the development risk of CHD in NAFLD patients. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.