However, the CG + GG genotype could decrease the risk of CHD in NAFLD patients (OR = 0.60, 95%CI: 0.40–0.90, P = 0.01), which suggested the protective role of PNPLA3 I148M for the risk of CHD in NAFLD patients. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.