The aim of this study was to explore the relationship of PNPLA3 I148M and TM6SF2 E167K variants with the risk of CHD in NAFLD patients in Chinese Han population, and explore the effects of PNPLA3 I148M and TM6SF2 E167K variants on the serum lipid profiles in overall series. The gene discussed is TM6SF2; the disease is coronary artery disorder.