A panel of three proteins (PI3K-p85α, EGFR and p53) has been identified as the independent prognostic factor in esophageal squamous cell carcinoma (ESCC), and the combination of a three protein panel with clinicopathological parameters, lymph node metastasis status and pathologic stage could classify patients into the different prognostic groups [25]. Here, TP53 is linked to esophageal squamous cell carcinoma.