Smoking history (P = 0.043), non-adenocarcinoma (P = 0.013), high architectural grade of LUAD (P = 0.019), EGFR wild status (P = 0.002), bone metastasis (P = 0.040) and brain metastasis (P = 0.042) were marginally correlated with worse PRS. This evidence concerns the gene EGFR and adenocarcinoma.