Taking the effect of clinicopathological variables on PRS into the account, smoking history (HR:1.266, 95%CI: 1.008–1.589; P = 0.043), non-adenocarcinoma (HR: 1.357, 95%CI: 1.074–1.762; P = 0.013), high architectural grade of LUAD (HR: 2.795, 95%CI:1.181–6.615; P = 0.019), EGFR wild status (HR:2.140, 95%CI: 1.307–3.503; P = 0.002), brain metastasis (HR: 1.442, 95%CI:1.013–2.051; P = 0.042) and bone metastasis (HR: 1.443, 95%CI:1.017–2.048; P = 0.040) were significantly related with worse PRS (Fig. 2). Here, EGFR is linked to bone metastasis.