Elevated activity of lysosomal cathepsins and, in particular, that of CATB, observed in several lysosomal diseases other than MPS, can be also explained by the nuclear translocation of TFEB that promotes expression of several hundred genes related to lysosomal catabolism and autophagy (so-called CLEAR network), including CTSB encoding for CATB [64]. This evidence concerns the gene CTSB and Lysosomal disease.