MTAP and central nervous system cancer: Overall, we found loss of MTAP mRNA expression in 33.3% (6/18) of the cell lines evaluated (Figure 2), particularly in 36.3% (4/11) of established cell lines, with 25% (1/4) for pediatric and 42.8% (3/7) for adult glioma cell lines (Figure 2A), and 29% (2/7) of patient-derived glioma cell lines (Figure 2B).