Therefore, MTAP has been reported as a tumor suppressor gene [24,26,27,28,29,30]; however, many studies have demonstrated the contradictory function of MTAP. For instance, the loss of MTAP expression has been associated with inhibition of growth and progression of head and neck carcinoma and lung cancer by MTA accumulation [31,32]. The gene discussed is MTAP; the disease is head and neck carcinoma.