Compound L61H10, a heterocyclic ketone derivative, has exerted the cancer inhibitory effects without obvious side effects both in lung cancer cells and in the nude mice bearing xenografts by arresting the cell cycle in the G2/M phase and mediating the switch of NF-κB-modulated apoptosis to caspase3/GSDME-mediated pyroptosis [79]. The gene discussed is GSDME; the disease is lung carcinoma.