A randomized control study of 158 men in eight Japanese centers using a purified isoflavone supplement reported no significant change in the PSA value before and after treatment, and the incidence of PCa showed no significant difference between isoflavone and placebo groups, although for patients aged >65 years, PCa incidence in the isoflavone group was significantly lower (28.0% vs. 57.1%) [116]. Here, KLK3 is linked to posterior cortical atrophy.