A previous study showed that the STAT3 pathway plays an important role in HFD-induced PCa progression in an animal model [30], whereas another study investigating prostate tissue from obese PCa-model mice revealed elevated levels of C-X-C motif chemokine ligand (CXCL)12, C-X-C motif chemokine receptor (CXCR)4, and CXCR7 and showed that a CXCR4 agonist inhibited the migration and invasion of PCa cell lines treated with CXCL12 [31]. Here, ACKR3 is linked to posterior cortical atrophy.