STAT3 and neoplasm: Further investigation showed that the mechanism involved local inflammation in the prostate gland induced by the HFD, which led to increased counts of tumor-infiltrating myeloid-derived suppressor cells and production of IL-6 by macrophages, thereby inducing PCa growth by suppression of tumor immunity and via the IL-6/signal transducer and activator of the transcription 3 (STAT3) signaling pathway [29].