However, there were variations in the activity of carotenoid cleavage enzymes, such as β-carotene 9′,10′-oxygenase 2 (BCO2), and the abilities of lycopene to inhibit PCa carcinogenesis were significantly attenuated in TRAMP Bco2−/− mice relative to those in TRAMP Bco2 wild-type mice [74]. Here, BCO2 is linked to posterior cortical atrophy.