As a support of the relevance of NSCLC histotype to consider the TLR3 prognostic role, the in silico analysis of KM-Plotter database showed a better outcome in TLR3 expressing adenocarcinoma and no association between TLR3 expression and prognosis in squamous NSCLC, both considering stage I and stage II NSCLC patients. This evidence concerns the gene TLR3 and non-small cell lung carcinoma.