PON2 and pancreatic ductal adenocarcinoma: In particular, the role played by PON2 as a metabolic regulator has been confirmed in a study carried out by Nagarajan et al. In pancreatic ductal adenocarcinoma (PDAC) cell lines, the authors demonstrated that PON2 transcriptional repression is responsible for affecting the transport activity of glucose transporter 1 and subsequently, for an inhibition of PDAC tumor growth and metastasis [25].