TP53 and cancer: The quantitative RT-PCR analysis showed an increase of 1.5 and 2-fold in the gene expression for caspase-8 gene and p53 gene at the GI50 concentration of Epiafzelechin when compared with untreated control while it indicated a decrease of 0.9 and 0.8 fold in the gene expression for β-catenin gene and CDK2 gene at the GI50 concentration of Epiafzelechin when compared with the untreated control in MG-63 cancer cells, as shown in Figure 17.