NR1H4 and hepatocellular carcinoma: Kettner et al. reported that chronic circadian disruption increased the morbidity of NAFLD, in particular making Fxr-/- mice prone to form non-alcoholic steatohepatitis (NASH) and even hepatocellular carcinoma (HCC), which revealed that disturbance of circadian rhythm was one of the causes of the formation of NAFLD [27].