In 494 HF patients Bayes-Genis et al. found that, the combination of both increased LA size (>26 mm/m2) and NT-proBNP (>908 ng/L) was associated with an eight-fold increased risk of SCD, resulting in a 25% risk of this event in the follow-up period of 36 months. The gene discussed is NPPB; the disease is Schnyder corneal dystrophy.