In the myocardium, early overnutrition was associated with a significant increase in the gene expression of the proinflammatory markers IL-1β (p < 0.05), IL-6 (p < 0.01), TNF- α (p < 0.05), and LO (p < 0.05), and the pro-oxidant enzymes NOX-1 (p < 0.05) and NOX-4 (p < 0.01). Here, NOX4 is linked to overnutrition.